The story is of the orphan Oliver Twist, who starts his life in a workhouse and is then sold into apprenticeship with an undertaker. He escapes from there and travels to London, where he meets the Artful Dodger, a member of a gang of juvenile pickpockets led by the elderly criminal Fagin.

Oliver Twist is notable for its unromantic portrayal by Dickens of criminals and their sordid lives, as well as for exposing the cruel treatment of the many orphans in London in the mid-19th century. The alternate title, The Parish Boy's Progress, alludes to Bunyan's The Pilgrim's Progress, as well as the 18th-century caricature series by William Hogarth, A Rake's Progress and A Harlot's Progress. Oliver Twist has been the subject of numerous adaptations for various media, including a highly successful musical play, Oliver!, and the multiple Academy Award-winning 1968 motion picture.