A young woman called Tina becomes the first victim of a mutated spider, beginning a horrific and bloodthirsty story set in the near future on the Island of Manhattan.

Two young, naïve scientists are frantically searching for the cure for Alzheimer's disease, but inadvertently contaminate the arachnid specimen. The whole of the Island, along with New York city itself must bear the brunt of the total devastation that follows.

If these bloodthirsty, black, hideous spiders cannot be stopped here and now, then the entire world will be overrun by these terrifying creatures, killing every man, woman and child on the planet.