The Scarlet Plague is a post-apocalyptic fiction novel written by Jack London and originally published in London Magazine in 1912.

The story takes place in 2073, sixty years after an uncontrollable epidemic, the Red Death, has depopulated the planet. James Howard Smith is one of the few survivors of the pre-plague era left alive in the San Francisco area, and as he realizes his time grows short, he tries to impart the value of knowledge and wisdom to his grandsons.

Jack London is an american author, best known of The Call of the Wild and White Fang, both set in the Klondike Gold Rush, as well as the short stories "To Build a Fire", "An Odyssey of the North", and "Love of Life". He also wrote of the South Pacific in such stories as "The Pearls of Parlay" and "The Heathen", and of the San Francisco Bay area in The Sea Wolf.